Flow cytometric immunophenotyping of plasma cells across the spectrum of plasma cell proliferative disorders: A fresh insight with pattern-based recognition.

Nupur DasMeetu DahiyaRitu GuptaSandeep RaiSaroj SinghVijay K PrajapatiLalit KumarAtul SharmaRanjit K SahooAjay Gogia

Published in: Cytometry. Part B, Clinical cytometry (2022)

Fair discrimination between NPC and APC is achievable in all PCPD samples using eight markers (Gating: CD38, CD138, CD45; PBR:CD19, CD56, CD27; clonality: Cy-kappa and Cy-lambda). Thus, combined assessment of clonality and immunophenotypic aberrancies is required for accurate, reliable and precise assessment of NPC and APC compartments in PCPD.

Keyphrases

induced apoptosis
nuclear factor
cell cycle arrest
cell therapy
nk cells
high resolution
endoplasmic reticulum stress
immune response
mass spectrometry
oxidative stress
signaling pathway
mesenchymal stem cells
toll like receptor