Effects of memantine on mania-like phenotypes exhibited by Drosophila Shaker mutants.

Ignazia MocciMaria Antonietta CasuValeria SogosAnna LisciaRossella AngiusFrancesca CadedduMaura FantiPatrizia MuroniGiuseppe TalaniAndrea DianaMaria ColluMaria Dolores Setzu

Published in: CNS neuroscience & therapeutics (2023)

Our results show the involvement of the glutamatergic system in the SH, given the interaction between the Shaker channel and the NMDA receptor, suggesting this model as a promising tool for studying the neurobiology of bipolar disorders. Moreover, our results show Mem as a potential disease-modifying therapy, providing insight on new mechanisms of action.

Keyphrases

bipolar disorder
human health
stem cells
mesenchymal stem cells
cell therapy
climate change
smoking cessation