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Activation of neutral sphingomyelinase 2 through hyperglycemia contributes to endothelial apoptosis via vesicle-bound intercellular transfer of ceramides.

Andreas ZietzerAlina Lisann JahnelMarko BulicKatharina GutbrodPhilip DüsingMohammed Rabiul HosenPeter DörmannNikos WernerGeorg NickenigFelix Jansen
Published in: Cellular and molecular life sciences : CMLS (2021)
lEVs mediate the induction of apoptosis in endothelial cells in response to hyperglycemic injury through intercellular transfer of ceramides.
Keyphrases
  • endothelial cells
  • endoplasmic reticulum stress
  • cell cycle arrest
  • oxidative stress
  • cell death
  • cell adhesion
  • high glucose
  • vascular endothelial growth factor
  • pi k akt
  • signaling pathway
  • cell proliferation