Crystalline and Amorphous Preparation of Aluminum Hydroxide Nanoparticles Enhances Protective Antigen Domain 4 Specific Immunogenicity and Provides Protection Against Anthrax.
Himanshu GogoiRajesh ManiSoumya AggarwalAnshu MalikManoj MundeRakesh BhatnagarPublished in: International journal of nanomedicine (2020)
These results demonstrate that size and crystallinity of AH nps play important roles in mediating enhanced antigen presenting cells (APCs) activation and potentiating a strong antigen-specific immune response, and are critical parameters for the rational design of alum-based Th1-type adjuvant to induce a more balanced antigen-specific immune response.
Keyphrases
- immune response
- induced apoptosis
- room temperature
- cell cycle arrest
- dendritic cells
- toll like receptor
- early stage
- endoplasmic reticulum stress
- case report
- oxide nanoparticles
- oxidative stress
- cell death
- signaling pathway
- mass spectrometry
- gold nanoparticles
- reduced graphene oxide
- cell proliferation
- pi k akt
- walled carbon nanotubes