Precise tetrafunctional streptavidin bioconjugates towards multifaceted drug delivery systems.

Dongdong XuAstrid Johanna HeckSeah Ling Kuan Tanja Weil Seraphine Valeska Wegner

Published in: Chemical communications (Cambridge, England) (2021)

The preparation of precise macromolecules with multiple functionalities remains a challenge in drug delivery. Here, a method to prepare stoichiometrically precise tetrafunctional streptavidin conjugates is presented with an exemplary structure combining exactly one fluorescent label, one cell targeting group, one nucleus penetrating peptide and one drug molecule.

Keyphrases

drug delivery
cancer therapy
single cell
cell therapy
quantum dots
living cells
stem cells
emergency department
mesenchymal stem cells
single molecule
bone marrow
fluorescent probe
solid phase extraction