Cutaneous ischemia-reperfusion injury is exacerbated by IL-36 receptor antagonist deficiency.
Y TanakaY IwataK SaitoHidehiko FukushimaSoichiro WatanabeY HasegawaMasashi AkiyamaK SugiuraPublished in: Journal of the European Academy of Dermatology and Venereology : JEADV (2021)
This study indicated that IL-36Ra deficiency exacerbates cutaneous I/R injury due to excessive inflammatory cell recruitment, NET formation, and excessive cytokine and chemokine production via the TLR4 pathway by HMGB1 released from epidermal apoptotic cells.
Keyphrases
- ischemia reperfusion injury
- induced apoptosis
- oxidative stress
- weight gain
- cell death
- cell cycle arrest
- single cell
- inflammatory response
- immune response
- toll like receptor
- replacement therapy
- signaling pathway
- stem cells
- systemic lupus erythematosus
- endoplasmic reticulum stress
- bone marrow
- mesenchymal stem cells
- weight loss