ELL2 Is Required for the Growth and Survival of AR-Negative Prostate Cancer Cells.

Zhi Wang Laura E PascalUma R ChandranSrilakshmi ChaparalaShidong LvHui DingLin QiZhou Wang

Published in: Cancer management and research (2020)

ELL2 knockdown in PC-3 and DU145 cells induced S-phase cell cycle arrest and profound apoptosis, which was accompanied by the induction of genes associated with cell death and survival pathways. These observations suggest that ELL2 is a potential oncogenic protein required for survival and proliferation in AR-negative prostate cancer cells.

Keyphrases

cell cycle arrest
cell death
pi k akt
signaling pathway
free survival
transcription factor
small molecule
risk assessment
high glucose
diabetic rats
protein protein
binding protein