Sub-fertility in crossbred bulls: deciphering testicular level transcriptomic alterations between zebu (Bos indicus) and crossbred (Bos taurus x Bos indicus) bulls.

Kamaraj ElangoArumugam KumaresanAnkur SharmaPradeep NagMani Arul PrakashManish Kumar SinhaAyyasamy ManimaranEbenezer Samuel King John PeterSakthivel JeyakumarSellappan SelvarajuKerekoppa P RameshaTirtha K Datta

Published in: BMC genomics (2020)

Abundant proteolysis by ubiquitination and downregulation of WNT signaling, cell proliferation, differentiation and steroidogenesis might be associated with higher incidence of poor semen quality and/or sub-fertility/infertility in crossbred bulls as compared to Zebu bulls. Downregulation of SPATA7 (Spermatogenesis Associated 7) and upregulation of transition proteins (TNP1 and TNP2) in crossbred bull testis might be associated with impaired spermatogenesis processes including improper chromatin compaction in crossbred bulls.

Keyphrases

cell proliferation
signaling pathway
cell cycle
dna damage
transcription factor
pi k akt
risk factors
single cell
germ cell
oxidative stress
childhood cancer