What is the impact of e-cigarettes on periodontal stem cells as revealed by transcriptomic analyses?
Carlos Fernando de Almeida Barros MourãoJamil A ShibliPublished in: Evidence-based dentistry (2023)
E-cigarettes affect oral stem cells differently than tobacco smoke. Their aerosol and liquid have varying impacts on gene expression and regulatory landscapes in oral cells. Multi-omics approaches are important to understanding the molecular changes caused by e-cigarette components. This can help with toxicological assessments and determine their impact on periodontal health. Transcriptome and epigenome profiling are powerful tools to examine the unique molecular mechanisms involved in cellular responses to e-cigarettes.
Keyphrases
- stem cells
- smoking cessation
- single cell
- gene expression
- dna methylation
- rna seq
- replacement therapy
- induced apoptosis
- healthcare
- public health
- cell therapy
- cell cycle arrest
- transcription factor
- mental health
- health information
- endoplasmic reticulum stress
- mesenchymal stem cells
- oxidative stress
- signaling pathway
- ionic liquid
- social media
- cell proliferation