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Integrative bioinformatics analysis characterizing the role of EDC3 in mRNA decay and its association to intellectual disability.

Ute SchellerKathrin PfistererSteffen UebeArif B EkiciAndré ReisRami JamraFulvia Ferrazzi
Published in: BMC medical genomics (2018)
Our data support the involvement of EDC3 in mRNA decay, including ARE-containing mRNAs, and suggest that EDC3 might be preferentially involved in the degradation of long coding and non-coding RNAs. Furthermore, our results associate ECD3 loss-of-function with synapses-related pathways. Collectively, our data provide novel information that might help elucidate the molecular mechanisms underlying the association of intellectual disability with the dysregulation of mRNA degradation.
Keyphrases
  • intellectual disability
  • autism spectrum disorder
  • bioinformatics analysis
  • electronic health record
  • binding protein
  • big data
  • healthcare
  • artificial intelligence
  • network analysis