The assessment of Dickkopf-1 and Dickkopf-2 protein concentration in different subtypes of non-small cell lung cancer subtypes.

Dorota HudyJadwiga GaździckaAgata ŚwiętekKarolina GołąbekMateusz RydelDamian CzyżewskiJoanna Katarzyna Strzelczyk

Published in: Contemporary oncology (Poznan, Poland) (2024)

We suggest that DKK-1 could play an oncogenic role in AC, while DKK-2 could be a tumour suppressor in all NSCLC subtypes. Dickkopf-1 and DKK-2 proteins could have differential roles in the Wnt signalling pathway, which is important in many cellular processes, such as proliferation and apoptosis.

Keyphrases

small cell lung cancer
cell proliferation
signaling pathway
endoplasmic reticulum stress
cell cycle arrest
protein protein
binding protein
pi k akt
tyrosine kinase