HHLA2 deficiency inhibits non-small cell lung cancer progression and THP-1 macrophage M2 polarization.

Wenjie SunShuying LiGuiliang TangShaoxing SunYuan LuoRui BaiLinzhi HanXueping JiangYanping GaoZhengrong HuangJunhong ZhangYan Gong Conghua Xie

Published in: Cancer medicine (2021)

HHLA2 downregulation inhibited NSCLC growth and TAM M2 polarization. HHLA2 may serve as a therapeutic target and promising prognostic biomarker in NSCLC.

Keyphrases

small cell lung cancer
advanced non small cell lung cancer
brain metastases
cell proliferation
signaling pathway
adipose tissue
replacement therapy