Insulin combined with N-acetylcysteine attenuates type 1 diabetes-induced splenic inflammatory injury in canines by inhibiting the MAPKs-NF-κB signaling pathway and pyroptosis.
Xinting ZhangWenyue QiuJianjia HuangXiaoyue PangYiman SuJiali YeShuilian ZhouZhaoxin TangRongmei WangRongsheng SuPublished in: Journal of diabetes and its complications (2024)
This combination has the potential to mitigate splenic inflammatory injury in T1DM canines by suppressing the activation of MAPKs-NF-κB pathway and pyroptosis. These findings provide a reference for the treatment strategies of diabetes and its complications.
Keyphrases
- signaling pathway
- type diabetes
- glycemic control
- pi k akt
- oxidative stress
- induced apoptosis
- nlrp inflammasome
- epithelial mesenchymal transition
- diabetic rats
- cardiovascular disease
- high glucose
- lps induced
- insulin resistance
- risk factors
- cell proliferation
- human health
- metabolic syndrome
- drug induced
- endothelial cells
- endoplasmic reticulum stress