A phenome-wide association study of genetically mimicked statins.
Shun LiCatherine Mary SchoolingPublished in: BMC medicine (2021)
Similar inverse associations were found for genetically mimicking statins on lipid traits in men and women as for other lipid modifiers. Besides the positive associations with HbA1c, BMI (which may explain the higher BMR), and aspects of body composition in men and women, genetically mimicking statins was additionally associated with platelet attributes in both sexes and was inversely associated with serum calcium and SHBG in women. This genetic evidence suggests potential pathways that contribute to the effects of statins particularly in women. Further investigation is needed to confirm these findings and their implications for clinical practice.
Keyphrases
- body composition
- cardiovascular disease
- polycystic ovary syndrome
- clinical practice
- resistance training
- bone mineral density
- genome wide
- pregnancy outcomes
- cervical cancer screening
- type diabetes
- gene expression
- insulin resistance
- dna methylation
- copy number
- pregnant women
- adipose tissue
- metabolic syndrome
- human health