Fecal Transplant in Children With Clostridioides difficile Gives Sustained Reduction in Antimicrobial Resistance and Potential Pathogen Burden.

Suchitra K HouriganMichelle AhnKeylie M GibsonMarcos Pérez-LosadaGrace FelixMelissa WeidnerIan LeibowitzJohn E NiederhuberCynthia L SearsKeith A CrandallMaria Oliva-Hemker

Published in: Open forum infectious diseases (2019)

FMT for CDI in children decreases AMR genes and potential pathogens and changes microbiota composition and function. However, acquisition of certain AMR genes post-FMT combined with low levels of potential pathogens found in donors suggests that further study is warranted regarding screening donors using metagenomics sequencing before FMT.

Keyphrases

antimicrobial resistance
young adults
genome wide
human health
gram negative
clostridium difficile
risk assessment
candida albicans
genome wide identification
transcription factor
high throughput sequencing