Deoxycholic Acid-Induced Gut Dysbiosis Disrupts Bile Acid Enterohepatic Circulation and Promotes Intestinal Inflammation.

Mengque XuMengsha CenYuqin ShenYubin ZhuFangli ChengLinlin TangWeiling HuNing Dai

Published in: Digestive diseases and sciences (2020)

These results suggest that DCA-induced gut dysbiosis may act as a key etiologic factor in intestinal inflammation, associated with bile acid metabolic disturbance and downregulation of the FXR-FGF15 axis.

Keyphrases

oxidative stress
diabetic rats
high glucose
cell proliferation
signaling pathway
drug induced