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Genome-wide association study of a nicotine metabolism biomarker in African American smokers: impact of chromosome 19 genetic influences.

Meghan J ChenowethJennifer J WareAndy Z X ZhuChristopher B ColeLisa Sanderson CoxNikki NollenJasjit S AhluwaliaNeal L BenowitzRobert A SchnollLarry W HawkPaul M CinciripiniTony P GeorgeCaryn LermanJoanne KnightRachel Fynvola Tyndalenull null
Published in: Addiction (Abingdon, England) (2017)
Three independent chromosome 19 signals account for ~20% of the variability in the nicotine metabolite ratio in African American smokers. The hits identified may contribute to inter-ethnic variability in nicotine metabolism, smoking behaviours and tobacco-related disease risk.
Keyphrases
  • african american
  • smoking cessation
  • genome wide association study
  • copy number
  • genome wide
  • drug induced