Genome-wide association study of a nicotine metabolism biomarker in African American smokers: impact of chromosome 19 genetic influences.
Meghan J ChenowethJennifer J WareAndy Z X ZhuChristopher B ColeLisa Sanderson CoxNikki NollenJasjit S AhluwaliaNeal L BenowitzRobert A SchnollLarry W HawkPaul M CinciripiniTony P GeorgeCaryn LermanJoanne KnightRachel Fynvola Tyndalenull nullPublished in: Addiction (Abingdon, England) (2017)
Three independent chromosome 19 signals account for ~20% of the variability in the nicotine metabolite ratio in African American smokers. The hits identified may contribute to inter-ethnic variability in nicotine metabolism, smoking behaviours and tobacco-related disease risk.