Single Injection AAV2-FGF18 Gene Therapy Reduces Cartilage Loss and Subchondral Bone Damage in a Mechanically Induced Model of Osteoarthritis.

Judith M Hollander Alexey SereginJingshu LiuEllyn XuFrancesco LuppinoTimothy E McAlindonLi ZengAlexey Seregin

Published in: Current gene therapy (2024)

FGF18 gene therapy treatment of OA joints can provide benefits to both cartilage and subchondral bone, with a high degree of localization and durability.

Keyphrases

gene therapy
bone mineral density
knee osteoarthritis
soft tissue
extracellular matrix
bone loss
high glucose
bone regeneration
oxidative stress
rheumatoid arthritis
diabetic rats
postmenopausal women
ultrasound guided
combination therapy
endothelial cells