Weaning Failure in Critically Ill Patients Is Related to the Persistence of Sepsis Inflammation.

Anna KyriakoudiNikoletta RovinaOurania KoltsidaEirini KostakouElissavet KonstantelouMatina KardaraMaria KompotiAnastasios PalamidasGeorgios KaltsakasAntonia Koutsoukou

Published in: Diagnostics (Basel, Switzerland) (2021)

Sustained increased levels of IL-18 and IL-18BP, acknowledged markers of sepsis, were found to be indicative of SBT failure in patients recovering from sepsis. Our results show that, although subclinical, remaining septic inflammation that sustaines for a long time complicates the weaning procedure. Biomarkers for the estimation of the septic burden and the right time for weaning are needed.

Keyphrases

acute kidney injury
mechanical ventilation
intensive care unit
septic shock
oxidative stress
end stage renal disease
newly diagnosed
ejection fraction
chronic kidney disease
peritoneal dialysis
minimally invasive
patient reported