Repetitive Antigen Responses of LDL-Reactive CD4+ T Cells Induce Tr1 Cell-Mediated Immune Tolerance.
Reiner K MailerSandra KonrathLydia ZhanHanna ThodeManu BeerensMaike FryeDaniel F J KetelhuthThomas RenneGöran K HanssonPublished in: Arteriosclerosis, thrombosis, and vascular biology (2023)
We show that repetitive transfer of naive ApoB100-specific T cells and recurrent LDL-specific T-cell stimulation induces Treg type 1 cell-mediated immune tolerance against LDL in vivo. Our results provide insight into the generation of autoantigen-specific anti-inflammatory T cells under tolerogenic conditions.