Synthesis and validation of [18F]mBPET-1, a fluorine-18 labelled mTOR inhibitor derivative based on a benzofuran backbone.
Christian Werner WichmannYit Wooi GohAdam C ParslowAngela RigopoulosNancy GuoAndrew M ScottUwe AckermannJonathan M WhitePublished in: EJNMMI radiopharmacy and chemistry (2020)
Molecular targeting of mTOR with [18F]mBPET-1 distinguishes mTOR inhibitor sensitive and insensitive cell lines. Future studies will explore the ability of [18F]mBPET-1 to predict response to mTOR inhibitor treatment in in vivo models.