Optimizing Precision Medicine for Breast Cancer Brain Metastases with Functional Drug Response Assessment.

Aki Morikawa Jinju Li Peter J Ulintz Xu Cheng Athena Apfel Dan R Robinson Alexander C Hopkins Chandan Kumar-Sinha Yi-Mi Wu Habib Serhan Kait Verbal Dafydd G Thomas Daniel F Hayes Arul M Chinnaiyan Veerabhadran Baladandayuthapani Jason Heth Matthew B Soellner Sofia Diana Merajver Nathan Merrill

Published in: Cancer research communications (2023)

Examining genomic alterations and differentially expressed pathways in brain metastases may inform future therapeutic strategies. This study supports genomically-guided therapy for BCBM and further investigation into incorporating real-time functional evaluation will increase confidence in efficacy estimations during drug development and predictive biomarker assessment for BCBM.

Keyphrases

brain metastases
small cell lung cancer
current status
copy number
gene expression