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Mechanistic Characterization of Cancer-associated Fibroblast Depletion via an Antibody-Drug Conjugate Targeting Fibroblast Activation Protein.

Joseph P GallantHallie M HintzGihan S GunaratneMatthew T BrenemanEmma E RecchiaJayden L WestKendahl L OttErika HeningerAbigail E JacksonNatalie Y LuoZachary T RosenkransReinier HernandezShuang G ZhaoJoshua M LangLabros MeimetisDavid KosoffAaron M LeBeau
Published in: Cancer research communications (2024)
The direct elimination of FAP-expressing CAFs disrupts the cross-talk with cancer cells leading to a proinflammatory response and alterations in the immune microenvironment and antitumor immune response.
Keyphrases
  • immune response
  • cancer therapy
  • stem cells
  • wound healing
  • protein protein
  • dendritic cells
  • toll like receptor