Pre- and post-conditioning with poly I:C exerts neuroprotective effect against cerebral ischemia injury in animal models: A systematic review and meta-analysis.

Zeeshan Ahmad KhanDewan Md SumsuzzmanJeonghyun ChoiGeorge KamenosYonggeun Hong

Published in: CNS neuroscience & therapeutics (2022)

We showed that poly I:C is neuroprotective and acts via the TLR3/NF-κB/TNF-α pathway. Our review indicated that suppressing TLR 2/4 may illicit neuroprotection against CI. Further research on simultaneous activation of TLR3 with poly I:C and suppression of TLR 2/4 might open new vistas for the development of therapeutics against CI.

Keyphrases

cerebral ischemia
toll like receptor
inflammatory response
subarachnoid hemorrhage
immune response
blood brain barrier
brain injury
nuclear factor
signaling pathway
rheumatoid arthritis
minimally invasive
small molecule
pi k akt