SARS-CoV-2 spike downregulates tetherin to enhance viral spread.

H StewartK H JohansenN McGovernR PalmulliG W CarnellJ L HeeneyK OkkenhaugA E FirthA A PedenJames R Edgar

Published in: bioRxiv : the preprint server for biology (2021)

SARS-CoV-2 downregulates the host restriction factor, tetherin.Tetherin loss enhances viral titre and spread.SARS-CoV-2 ORF7a protein does not downregulate tetherin, but instead induces Golgi fragmentation.Tetherin downregulation is mediated by SARS-CoV-2 spike.

Keyphrases

sars cov
respiratory syndrome coronavirus
cell proliferation
coronavirus disease
binding protein