Cyclophilin D induces necrotic core formation by mediating mitochondria-associated macrophage death in advanced atherosclerotic lesions.
Jun-Ichiro KogaRyuta UmezuYuki KondoTomohiro ShirouzuNasanbadrakh OrkhonselengeHiromichi UenoShunsuke KatsukiTetsuya MatobaYosuke NishimuraMasaharu KataokaPublished in: Atherosclerosis (2024)
These results indicate that CypD induces macrophage death and mediates necrotic core formation in advanced atherosclerotic lesions. CypD could be a novel therapeutic target for treating atherosclerotic vascular diseases.
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