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Iron(0)-Mediated Stereoselective (3+2)-Cycloaddition of Thiochalcones via a Diradical Intermediate.

Philipp BudayPhillip SeeberClara ZensHassan Abul-FutouhHelmar GörlsStefanie GräfePiotr MatczakStefanie GräfeWolfgang WeigandGrzegorz Mloston
Published in: Chemistry (Weinheim an der Bergstrasse, Germany) (2020)
Reactions of α,β-unsaturated aromatic thioketones 1 (thiochalcones) with Fe3 (CO)12 leading to η4 -1-thia-1,3-diene iron tricarbonyl complexes 2, [FeFe] hydrogenase mimics 3, and the thiopyrane adduct 4 are described. Obtained products have been characterized by X-ray crystallography and by computational methods. Completely regio- and diastereoselective formation of the five-membered ring system in products 3, containing four stereogenic centers, can be explained by an unprecedented, stepwise (3+2)-cycloaddition of two thiochalcone molecules mediated by Fe3 (CO)12 . Quantum chemical calculations aimed at elucidation of the reaction mechanism, suggest that the formal (3+2)-cycloaddition proceeds via sequential intramolecular radical transfer events upon homolytic cleavage of one carbon-sulfur bond leading to a diradical intermediate.
Keyphrases
  • molecular dynamics
  • high resolution
  • density functional theory
  • metal organic framework
  • molecular dynamics simulations
  • energy transfer
  • monte carlo
  • magnetic resonance imaging
  • computed tomography
  • visible light