Role of immune microenvironment in gastrointestinal stromal tumours.

Andrew M BlakelyAndres MatosoPallavi A PatilRoss TalianoJason T MachanThomas J MinerKara A LombardoMurray B ResnickLi-Juan Wang

Published in: Histopathology (2017)

PD-L1 expression was associated with increased size and mitoses. High CD8+ or CD3+ TIL counts were associated with decreased PD-L1/IDO+ GIST size. PD-L1 and IDO could be significant in GIST tumour biology, which invites consideration of immunotherapy as a potential treatment option.

Keyphrases

stem cells
nk cells
peripheral blood
combination therapy
risk assessment
climate change
replacement therapy