Association of Slowly Expanding Lesions on MRI With Disability in People With Secondary Progressive Multiple Sclerosis.
Alberto CalviFerran Prados CarrascoCarmen TurDeclan T ChardJonathan StuttersFloriana De AngelisNevin A JohnThomas WilliamsAnisha DoshiRebecca S SamsonDavid MacManusClaudia A M Gandini Wheeler-KingshottOlga CiccarelliJeremy ChatawayFrederik Barkhofnull nullPublished in: Neurology (2022)
Definite SELs represent almost one-third of T2 lesions in SPMS. They are associated with neurodegenerative MRI markers and related to clinical worsening, suggesting that they may contribute to disease progression and be a new target for therapeutic interventions.