Relationship between Innate Immune Response Toll-Like Receptor 4 (TLR-4) and the Pathophysiological Process of Obesity Cardiomyopathy.
Pedro Henrique Rizzi AlvesArtur Junio Togneri FerronMariane Róvero CostaFabiana Kurokawa HasimotoCristina Schmitt GregolinJessica Leite GarciaDijon Henrique Salomé de CamposAntônio Carlos CicognaLetícia de MatteiFernando MoretoSilméia Garcia Zanati BazanFabiane Valentini FrancisquetiCamila Renata CorrêaPublished in: Arquivos brasileiros de cardiologia (2021)
Our findings conclude that, in an obesogenic condition, the inflammation derived from cardiac TLR-4 activation can be a mechanism able to lead to remodeling and cardiac dysfunction.