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Modulating gut microbiota prevents anastomotic leak to reduce local implantation and dissemination of colorectal cancer cells after surgery.

Roy HajjarManon OlieroGabriela FragosoAyodeji Samuel AjayiAhmed Amine AlaouiHervé Vennin RendosAnnie CalvéThibault CuisiniereClaire GerkinsSophie ThérienNassima TalebFrançois DagbertHerawaty SebajangRasmy LoungnarathFrank SchwenterRichard RatelleRamses WassefEric De BrouxCarole RichardManuela M Santos
Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
Our findings reinforce the hypothesis that preventing AL is paramount to improving oncological outcomes after CRC surgery. Furthermore, they pave the way toward dietary targeting of PPAR-γ as a novel way to enhance healing and diminish cancer recurrence.
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