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Reduced serum immunoglobulin G concentrations in multiple sclerosis: prevalence and association with disease-modifying therapy and disease course.

Greta ZoehnerAndrei MicleaAnke SalmenNicole KamberLara DiemChristoph FriedliMaud BagnoudFarhad AhmadiMyriam BrinerNazanin Sédille-MostafaieConstantinos KilidireasLeonidas StefanisAndrew ChanRobert HoepnerMaria Eleftheria Evangelopoulos
Published in: Therapeutic advances in neurological disorders (2019)
Our study demonstrated high prevalence rates of reduced serum IgG concentrations in MS patients with and without disease-modifying treatments. The significance of lower IgG concentrations at the levels noted is unclear considering that infections or interference with antibody production generally occur when IgG levels are much lower, at or below 400 mg/dl. However, the information is useful to monitor IgG levels especially with anti-B-cell therapies and consider IgG substitution when levels drop below 400 mg/dl.
Keyphrases
  • multiple sclerosis
  • risk factors
  • mass spectrometry
  • healthcare
  • stem cells
  • ms ms
  • white matter
  • health information