Erythrocyte P2X1 receptor expression is correlated with change in haematocrit in patients admitted to the ICU with blood pathogen-positive sepsis.

Steen K FagerbergParth PatelLars W AndersenXiaowen LuiMichael W DonninoHelle A Praetorius

Published in: Critical care (London, England) (2018)

High levels of P2X1 are correlated with more pronounced reduction in haematocrit and haemoglobin in patients with confirmed bacteraemia. This supports previous in vitro findings of P2X activation as a significant component in cell damage caused by pore-forming bacterial toxins and complement-dependent major attack complex. These data suggest a new potential target for future therapeutics in initial stages of sepsis.

Keyphrases

intensive care unit
septic shock
acute kidney injury
single cell
cell therapy
oxidative stress
electronic health record
small molecule
current status
mechanical ventilation
big data
candida albicans
bone marrow
mesenchymal stem cells
deep learning