INitial Steps of Insulin Action in Parotid Glands of Male Wistar Rats.
André Guaraci DeVito-MoraesVictor Di Donato MarquesLuciana Chagas CaperutoFlavia Kazue IbukiFernando Neves NogueiraCarlos Eduardo FrancciCarla Roberta de Oliveira CarvalhoPublished in: Cell biochemistry and biophysics (2021)
The parotid gland is the largest salivary gland. It produces watery saliva, rich in proteins (amylase, lysozymes, and antibodies). Due to the gland's morphological cytoarchitecture composed of only serous acini, it contributes almost 50% of total salivary volume upon stimulation. It has been reported that the prevalence of saliva secretion impairments, periodontitis, delayed wound healing, and xerostomia increase in diabetic patients. Herein we evaluated the acute effects of insulin on insulin receptor phosphorylation status and its substrates IRS-1 and IRS-2 in the parotid glands of adult male Wistar rats, using Western blot analyses. We confirmed an acute effect of insulin on IR/IRS/PI3K/Akt and MAPK intracellular pathway activation in the parotid glands of male Wistar rats similar to the classical metabolic targets of the hormone, like the liver.
Keyphrases
- type diabetes
- pi k akt
- signaling pathway
- glycemic control
- liver failure
- cell proliferation
- wound healing
- high grade
- risk factors
- aortic dissection
- drug induced
- cell cycle arrest
- south africa
- oxidative stress
- adipose tissue
- cell death
- young adults
- intensive care unit
- protein kinase
- extracorporeal membrane oxygenation
- mechanical ventilation