Simulating autosomal genotypes with realistic linkage disequilibrium and a spiked-in genetic effect.

Min ShiD M UmbachA S WiseC R Weinberg

Published in: BMC bioinformatics (2018)

We have proposed a method for simulating genome-wide SNP data with realistic linkage disequilibrium. Our method will be useful for developing statistical methods for studying genetic associations, including higher order effects like epistasis and gene by environment interactions.

Keyphrases

genome wide
dna methylation
copy number
electronic health record
gene expression
big data
machine learning
human immunodeficiency virus
high density
hiv testing
genome wide identification