Asperemestrins A-D, Emestrin Hybrid Polymers with Bridged Skeletons from the Endophytic Fungus Aspergillus nidulans .
Qin LiAimin FuMengsha WeiYang XiaoJie YinJianzheng HuangXiao-Nian LiQingyi TongChunmei ChenHucheng ZhuYong-Hui ZhangPublished in: Organic letters (2022)
Four emestrin hybrid polymers, asperemestrins A-D ( 1-4 , respectively), were isolated from the fungus Aspergillus nidulans . Asperemestrins A-C are the first examples of emestrin-sterigmatocystin heterodimers bearing a 7/5/6/6/5/5/6/6/6 nonacyclic system with a 2,5-diazabicyclo[2.2.2]octane-3,6-dione core, while asperemestrin D features an unprecedented 2,15-dithia-17,19-diazabicyclo[14.2.2]icosa-4,8-diene-12,18,20-trione core skeleton. Their structures were determined by extensive spectroscopic data, electronic circular dichroism calculations, and single-crystal X-ray diffraction. Asperemestrin B showed moderate cytotoxicity against cancer cell lines, including SU-DHL-2, HEPG2, and HL-60.
Keyphrases
- high resolution
- papillary thyroid
- molecular docking
- cell wall
- squamous cell
- electronic health record
- density functional theory
- molecular dynamics
- electron microscopy
- molecular dynamics simulations
- high intensity
- big data
- lymph node metastasis
- computed tomography
- dual energy
- magnetic resonance imaging
- squamous cell carcinoma
- childhood cancer
- crystal structure
- mass spectrometry
- data analysis
- solid state
- contrast enhanced