Folate and Pegylated Aliphatic Polyester Nanoparticles for Targeted Anticancer Drug Delivery.

Avgi TsolouEftychia AngelouStylianos DidaskalouDimitrios N BikiarisKonstantinos AvgoustakisBogos AgianianMaria D Koffa

Published in: International journal of nanomedicine (2020)

Our data provide evidence that Paclitaxel-loaded-FA-PPSu-PEG-NPs can be used for targeted delivery of the drug, FA-PPSu-PEG-NPs can be used as vehicles for other anticancer drugs and their cellular uptake is mediated through a combination of FOLR1 receptor-specific endocytosis, and macropinocytosis. The exploration of the different cellular uptake mechanisms could improve treatment efficacy or allow a decrease in dosage of anticancer drugs.

Keyphrases

drug delivery
cancer therapy
drug release
drug induced
electronic health record
big data
artificial intelligence
binding protein
data analysis
adverse drug
combination therapy