Targeting HIF-1α by newly synthesized Indolephenoxyacetamide (IPA) analogs to induce anti-angiogenesis-mediated solid tumor suppression.

Fares Hezam Al-OstootAnkith SherapuraVigneshwaran VGiridhara BasappaVivek H KPrabhakar B TShaukath Ara Khanum

Published in: Pharmacological reports : PR (2021)

The IPA (8k) is a potent anti-proliferative molecule with anti-angiogenic activity and specifically targets HIF1α, thereby modulates its downstream regulatory genes both in vitro and in vivo. The study provides scope for new target-specific drug development against HIF-1α for the treatment of solid tumors.

Keyphrases

endothelial cells
transcription factor
vascular endothelial growth factor
cancer therapy
drug delivery
combination therapy
smoking cessation
molecular dynamics simulations
genome wide identification