Resolving the pathogenesis of anaplastic Wilms tumors through spatial mapping of cancer cell evolution.

Bahar Rastegar Natalie Andersson Alexandra Petersson Jenny Karlsson Subhayan Chattopadhyay Anders Valind Caroline Jansson Geoffroy Durand Patrik Romerius Karin Jirström Linda Holmquist Mengelbier David Gisselsson

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)

WTs with DA display significantly more complex phylogenies compared to non-DA WTs, including features of saltatory and parallel evolution. The subclonal landscape of individual tumors was constrained by anatomic compartments, which should be considered when sampling tissue for precision diagnostics.

Keyphrases

high resolution
single cell