Emergence of OXA-232 Carbapenemase-Producing Klebsiella pneumoniae That Carries a pLVPK-Like Virulence Plasmid among Elderly Patients in China.
Lingbin ShuNing DongJun LuZhiwei ZhengJie HuWenqing ZengQiaoling SunEdward Wai-Chi ChanHongwei ZhouFupin HuSheng ChenRong ZhangPublished in: Antimicrobial agents and chemotherapy (2019)
This study reported the clonal dissemination of OXA-232-producing sequence type 15 (ST15) carbapenem-resistant Klebsiella pneumoniae among elderly patients in China. All patients were immunocompromised, suffered from multiple underlying diseases, and were hospitalized for a prolonged period; however, they slowly recovered on antimicrobial therapy. The bla OXA-232 gene was in a 6.1-kb ColKP3-type nonconjugative plasmid. The strains displayed a multidrug resistance phenotype and were not hypervirulent despite harboring a virulence plasmid. Active surveillance should be enforced to control further transmission.
Keyphrases
- klebsiella pneumoniae
- escherichia coli
- end stage renal disease
- biofilm formation
- multidrug resistant
- staphylococcus aureus
- chronic kidney disease
- newly diagnosed
- ejection fraction
- prognostic factors
- peritoneal dialysis
- copy number
- pseudomonas aeruginosa
- genome wide
- gene expression
- mesenchymal stem cells
- drug resistant
- intensive care unit
- cystic fibrosis
- gram negative
- extracorporeal membrane oxygenation
- genome wide identification
- respiratory failure
- replacement therapy