New biallelic mutations in PADI6 cause recurrent preimplantation embryonic arrest characterized by direct cleavage.

Wei ZhengLongbin ChenJing DaiCan DaiJing GuoChangfu LuFei GongGuangxiu LuGe Lin

Published in: Journal of assisted reproduction and genetics (2019)

This study expands the mutation spectrum of PADI6 and is the first to propose that the preimplantation embryonic arrest with concomitant abnormal cleavage behaviors, especially DC, maybe associated with PADI6 mutations.

Keyphrases

cell cycle
dna binding
dendritic cells
transcription factor
cell proliferation