Evidence for interictal blood-brain barrier dysfunction in people with epilepsy.
Johannes T ReiterFreya SchulteTobias BauerBastian DavidChristoph EndlerAlexander IsaakFabiane SchuchFelix BitzerJuri-Alexander WittElke HattingenRalf DeichmannUlrike AttenbergerAlbert J BeckerChristoph HelmstaedterAlexander RadbruchRainer SurgesAlon FriedmanTheodor RuberPublished in: Epilepsia (2024)
Our results indicate a blood-brain barrier dysfunction in drug-resistant epilepsy that is detectable interictally in vivo, anatomically related to the presumed seizure onset zone, and associated with cognitive deficits.