Reversal of alopecia areata, osteoporosis follow treatment with activation of Tgr5 in mice.

Xiaohui ZhouZhiqiang GuanXiao JinJianbin ZhaoGuisheng ChenJicun DingYile RenXiaoxiang ZhaiQiyun ZhouZhiyuan Guan

Published in: Bioscience reports (2022)

These findings indicate that activation of Tgr5 mediated amelioration of alopecia areata and osteoporosis by down-regulated JAK1-STAT3 signaling pathway.

Keyphrases

postmenopausal women
signaling pathway
bone mineral density
transcription factor
epithelial mesenchymal transition
pi k akt
high fat diet induced
body composition
cell proliferation
adipose tissue
metabolic syndrome
induced apoptosis
combination therapy
skeletal muscle
endoplasmic reticulum stress
wild type