Deep and Prolonged Response to Aurora A Kinase Inhibitor and Subsequently to Nivolumab in MYCL1-Driven Small-Cell Lung Cancer: Case Report and Literature Review.
Bhaskar C KollaEmilian RacilaManish R PatelPublished in: Case reports in oncological medicine (2020)
Small-cell lung carcinoma (SCLC) is one of the most aggressive solid tumors, and the prognosis has not improved significantly in 25 years. Despite a recent understanding of the genomic aberrations seen in SCLC, these insights have not led to any breakthroughs in treatment. We present a patient with SCLC harboring a novel MYCL1 fusion protein who experienced a prolonged disease course due to the use of Aurora A kinase inhibitor and subsequently nivolumab. MYC family genes are master regulators of several cellular pathways including proliferation, differentiation, and apoptosis and recently have been shown to be involved in tumor immune evasion. Large studies have shown that a significant proportion of patients with SCLC have amplification or overexpression of MYC family genes. Preclinical data have exposed vulnerability of MYC-driven tumors to Aurora kinase inhibitors, bromodomain and extraterminal domain inhibitors, and recently to immune checkpoint blockers. Further studies using these agents with selective enrolling of patients with MYC-altered tumors are warranted to exploit these vulnerabilities.
Keyphrases
- transcription factor
- small cell lung cancer
- genome wide identification
- genome wide
- copy number
- cell therapy
- case control
- climate change
- cell proliferation
- signaling pathway
- cell death
- single cell
- endoplasmic reticulum stress
- big data
- bioinformatics analysis
- machine learning
- stem cells
- dna methylation
- mesenchymal stem cells
- nucleic acid
- angiotensin converting enzyme
- combination therapy
- deep learning