A Novel Paradigm for Non-Invasive Prenatal Genetic Screening: Trophoblast Retrieval and Isolation from the Cervix (TRIC).
Kirim HongHee Jin ParkHee Yeon JangSung Han ShimYoon JangSoo-Hyun KimDong-Hyun ChaPublished in: Diagnostics (Basel, Switzerland) (2023)
As the prevalence of pregnancies with advanced maternal age increases, the risk of fetal chromosomal abnormalities is on the rise. Therefore, prenatal genetic screening and diagnosis have become essential elements in contemporary obstetrical care. Trophoblast retrieval and isolation from the cervix (TRIC) is a non-invasive procedure that can be utilized for prenatal genetic diagnosis. The method involves the isolation of fetal cells (extravillous trophoblasts) by transcervical sampling; along with its non-invasiveness, TRIC exhibits many other advantages such as its usefulness in early pregnancy at 5 weeks of gestation, and no interference by various fetal and maternal factors. Moreover, the trophoblast yields from TRIC can provide valuable information about obstetrical complications related to abnormal placentation even before clinical symptoms arise. The standardization of this clinical tool is still under investigation, and the upcoming advancements in TRIC are expected to meet the increasing need for a safe and accurate option for prenatal diagnosis.
Keyphrases
- gestational age
- pregnant women
- birth weight
- preterm birth
- copy number
- genome wide
- pregnancy outcomes
- risk factors
- induced apoptosis
- cell cycle arrest
- gene expression
- oxidative stress
- quality improvement
- social media
- body mass index
- endoplasmic reticulum stress
- health information
- physical activity
- pi k akt
- pain management
- chronic pain
- health insurance
- affordable care act