Myeloid cell-derived interleukin-6 induces vascular dysfunction and vascular and systemic inflammation.
Tanja KnoppRebecca JungJohannes WildMagdalena L BochenekPanagiotis EfentakisAnnika LehmannTabea BielerVenkata GarlapatiCindy RichterMichael MolitorKatharina PeriusStefanie FingerJérémy LagrangeIman GhasemiKonstantinos ZifkosKatharina S KommossJoumana MasriSonja ReißigVoahanginirina RandriamboavonjyThomas WunderlichNadine HövelmeyerAlexander N R WeberIlgiz A MufazalovMarkus BosmannIngo BechmannIngrid FlemingMatthias OelzeAndreas DaiberThomas MunzelKatrin SchäferPhilip WenzelEsther Von StebutSusanne Helena KarbachPublished in: European heart journal open (2024)
Mice with conditional overexpression of IL-6 in myeloid cells show systemic and vascular inflammation as well as endothelial dysfunction. A decrease in circulating IL-6 levels by replacing IL-6-producing myeloid cells in the BM improved vascular dysfunction in this model, underpinning the relevant role of IL-6 in vascular disease.