Beta-adrenergic signaling and T-lymphocyte-produced catecholamines are necessary for interleukin 17A synthesis.
Tatlock H LautenSafwan K ElkhatibTamara NatourEmily C ReedCaroline N JojoAdam J CasePublished in: bioRxiv : the preprint server for biology (2024)
Our data depict a novel role for β1/2 adrenergic receptors and autologous catecholamine signaling during T-lymphocyte IL-17A production. These findings provide a new target for pharmacological therapy in both psychiatric and autoimmune diseases associated with IL-17A-related pathology.