Protein kinase C and protein kinase A are involved in the protection of recombinant human glucagon-like peptide-1 on glomeruli and tubules in diabetic rats.
Weiqin YinYongwei JiangShiqing XuZai WangLiang PengQing FangTingting DengWanni ZhaoWenjian ZhangJinning LouPublished in: Journal of diabetes investigation (2018)
These findings suggest that rhGLP-1 can reverse diabetic nephropathy by protecting both glomeruli and tubules by inhibiting PKC and activating PKA.