Mifepristone blocks the anxiolytic- and antidepressant-like effects of allopregnanolone in male rats.
Divya ChoudharyR B SasibhushanaB S Shankaranarayana RaoBettadapura N SrikumarPublished in: The International journal of neuroscience (2022)
The current study provides evidence for the first time that progestin or glucocorticoid receptors are involved in the acute anxiolytic and antidepressant effects of allopregnanolone. Understanding the mechanism of action of allopregnanolone will help us design better therapeutic strategies to treat neuropsychiatric diseases such as depression and anxiety.