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Tackling tumor microenvironment through epigenetic tools to improve cancer immunotherapy.

Iris LodewijkSandra P NunesRui HenriqueCarmen JerónimoMarta DueñasJesus M Paramio
Published in: Clinical epigenetics (2021)
Thus, modulating epigenetics in combination with immunotherapy might be a promising therapeutic option to improve the success of this therapy. Further studies are necessary to (1) understand in depth the impact of the epigenetic machinery in the tumor microenvironment; (2) how the epigenetic machinery can be modulated according to tumor type to increase response to immunotherapy and (3) find reliable biomarkers for a better selection of patients eligible to immunotherapy.
Keyphrases
  • dna methylation
  • gene expression
  • end stage renal disease
  • ejection fraction
  • newly diagnosed
  • chronic kidney disease
  • prognostic factors
  • optical coherence tomography